10 Years Manufacturer American Ginseng Extract to Jamaica Manufacturers
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Our previous studies have shown that Ginkgo biloba extract increased endothelial progenitor-cell (EPC) numbers and functional activity. However, the mechanisms remain to be determined. Recent studies have demonstrated that increased EPC numbers and activity were associated with the inhibition of EPC senescence, which involved activation of telomerase. Therefore, we investigated whether Ginkgo biloba extract inhibited the onset of EPC senescence through telomerase activation, leading to potentiation of cellular activity. After ex vivo cultivation, EPCs became senescent as determined by acidic ss-galactosidase staining. Ginkgo biloba extract dose-dependently prevented the onset of EPC senescence in culture. Moreover, Ginkgo biloba extract increased proliferation of EPCs as assessed by MTT assay and colony-forming capacity. To get further insights into the underlying mechanisms of these effects, we measured telomerase activity and determined the phosphorylation of Akt by Western blotting. Ginkgo biloba extract significantly increased telomerase activity and phosphorylation of the serine/threonine protein kinase Akt, a downstream effector of phosphoinositide 3-kinase (PI3K). Moreover, pretreatment with PI3K inhibitor, LY294002, significantly attenuated the Ginkgo biloba extract-induced telomerase activity. Taken together, the results indicated that Ginkgo biloba extract delayed the onset of EPC senescence, which may be related to activation of telomerase through the PI3k/Akt signaling pathway. The inhibition of EPC senescence by Ginkgo biloba extract in vitro may improve the functional activity of EPCs in a way that is important for potential cell therapy. SEO
If you want to start your day off right, this is the smoothie recipe for you. It’s chock-full of nutrients and tastes delicious thanks to the addition of beautiful Ambrosia apples.
We asked nutritional researcher and best-selling author, Brad King how he likes to start his day. He was happy to share his breakfast smoothie recipe and enlighten us on why it’s so good for us.
What’s the main ingredient? Ambrosia apples, of course. Brad reveals that Ambrosia apples are a good source of pectin and polyphenols. In this video, he explains how these two things can help you looking and feeling vibrant. What a great way to start the day!
Find out more about the health benefits of apples on our website: http://www.ambrosiaapples.com
The nutritional and medical views expressed in this video are the sole opinions of Brad King and are not reflective of views shared by NVDC. The information here is not intended as substitution for professional advice.
For more information about Brad King and his book, visit dirtydiets.net