Special Design for Grape Seed Extract for Bulgaria Factories

Special Design for Grape Seed Extract for Bulgaria Factories

Short Description:

A. Basic information Product name Grape Seed Extract Source of plant Vitis vinifera L Active ingredient Oligomeric Proantho Cyanidins(OPC) Specification OPCs95%( oligomer 85%), Polyphenol 70%/80% Catechinic & epicatechin≤19%; OEM accepted Solvent for extraction Ethyl alcohol B. Main function a) Super oxidation resistance,Scavenge redundant free radicals,Obvious anti-aging effect. Protective act...


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Special Design for Grape Seed Extract for Bulgaria Factories Detail:

A. Basic information

Product name

Grape Seed Extract

Source of plant

Vitis vinifera L

Active ingredient

Oligomeric Proantho Cyanidins(OPC)

Specification

OPCs95% oligomer 85%), Polyphenol 70%/80%

Catechinic & epicatechin≤19%; OEM accepted

Solvent for extraction

Ethyl alcohol

B. Main function

a) Super oxidation resistanceScavenge redundant free radicalsObvious anti-aging effect. Protective action on skin, eyes, teeth, prostate, cranial nerve.

b) Angiocarpy protectionimprove vascular elasticityprevention thrombosis and hypertension.


C. Critical To Quality

Ø Finger-print identification

Ø Content of active substance

Ø Control of solvent & pesticide residue


D. Quality control & Product Advantage

Grape seed used prior to fermentation, fine quality plant source 

QA&QC systemStrictly executing documented procedure prevention management, quality assured.

Leading technology of separation and purification, the first to use freeze-drying technology.

Technical advantageSharing of professional product identification techniques

Various specifications, OEM accepted

E. Product specification

Content of active ingredient

Name

OPCs 

OPCs oligomer

Polyphenol

Catechinic & epicatechin

Grape Seed Extract

95%

85%

70~95%

≤19%

          OEM all specifications of grape seed extract

Item

Testing standard

Testing method

Character

Appearance

Light brown to sepia powder

Sensory evaluation

Identification

Odor

Light odor and taste light bitter

Sensory evaluation

Fingerprints

conforms with standard

HPLC

Examination

Particle size

100% 80 mesh through

ChP2015<0982>

Loss on drying

NMT 6.0%

GB 5009.3

Ash content

NMT 5.0%

GB 5009.4

Bulk density

bulk density 0.30~0.55g/mL;

Internal method

Assay

OPC,%

NLT 95.0%

SW 1-2015

Polyphenol,%

NLT 70.0%

Catechinic & epicatechin,HPLC

NMT 19.0%

Solvent residues

Ethyl alcohol

   NMT 1000mg/kg

GB/T 5009.19

Methyl alcohol

 NMT 50mg/kg

GB/T 5009.19

Heavy metal

Heavy metal(in Pb)

  NMT 20.0mg/kg

GB/T 5009.74

Lead

 NMT 3.0mg/kg

GB 5009.12

Arsenic

 NMT 1.0mg/kg

GB/T 5009.11

Mercury

 NMT 0.1mg/kg

GB/T 5009.17

Cadmium

 NMT 1.0mg/kg

GB/T 5009.15

Pesticide residues

HCH

NMT 0.05ppm

ChP2015<2341>

DDT

NMT 0.05ppm

ChP2015<2341>

Microorganism

Total plate count

  NMT 1000CFU/g

GB 4789.2

Mould

NMT 50CFU/g

GB 4789.15

Yeast

NMT 50CFU/g

GB 4789.15

Escherichia coli

Not be detected

GB 4789.38

Pathogenic bacteria(salmonella,shigella,staphylococcus aureus,streptococcus hemolyticus)

Not be detected

GB 4789.4/ 5/ 10/ 11












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Special Design for Grape Seed Extract for Bulgaria Factories detail pictures


Special Design for Grape Seed Extract for Bulgaria Factories, The product will supply to all over the world, such as: , , ,



  • Video abstract of original research paper ‘Video abstract bioavailability’ to be published in the open access International Journal of Nanomedicine by Neves AR, Lúcio M, Martins S, et al.

    Introduction: Resveratrol is a polyphenol found in grapes and red wines. Interest in this polyphenol has increased due to its pharmacological cardio- and neuroprotective, chemopreventive, and antiaging effects, among others. Nevertheless, its pharmacokinetic properties are less favorable, since the compound has poor bioavailability, low water solubility, and is chemically unstable. To overcome these problems, we developed two novel resveratrol nanodelivery systems based on lipid nanoparticles to enhance resveratrol’s oral bioavailability for further use in medicines, supplements, and nutraceuticals.

    Methods and materials: Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) loaded with resveratrol were successfully produced by a modified hot homogenization technique. These were completely characterized to evaluate the quality of the developed resveratrol-loaded nanoparticles.

    Results: Cryo-scanning electron microscopy morphology studies showed spherical and uniform nanoparticles with a smooth surface. An average resveratrol entrapment efficiency of ~70% was obtained for both SLNs and NLCs. Dynamic light scattering measurements gave a Z-average of 150–250 nm, polydispersity index of ~0.2, and a highly negative zeta potential of around −30 mV with no statistically significant differences in the presence of resveratrol. These characteristics remained unchanged for at least 2 months, suggesting good stability. Differential scanning calorimetry studies confirmed the solid state of the SLNs and NLCs at both room and body temperatures. The NLCs had a less ordered crystalline structure conferred by the inclusion of the liquid lipid, since they had lower values for phase transition temperature, melting enthalpy, and the recrystallization index. The presence of resveratrol induced a disorder in the crystal structure of the nanoparticles, suggesting a favoring of its entrapment. The in vitro release studies on conditions of storage showed a negligible resveratrol release over several hours for both nanosystems and the in vitro simulation of gastrointestinal transit showed that the resveratrol remained mostly associated with the lipid nanoparticles after their incubation in digestive fluids.

    Conclusion: Both nanodelivery systems can be considered suitable carriers for oral administration, conferring protection to the incorporated resveratrol and allowing a controlled release after uptake.

    Read the full paper here: https://www.dovepress.com/articles.php?article_id=11880



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