Wholesale Dealers of Asian Ginseng Extract Export to South Africa

Wholesale Dealers of Asian Ginseng Extract Export to South Africa

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Wholesale Dealers of Asian Ginseng Extract Export to South Africa, The product will supply to all over the world, such as: , , ,



  • Cerebral ischemia is the interruption of blood flow to the brain. The lack of oxygen and glucose triggers a cascade of cellular events culminating in cell death, via necrosis or apoptosis. For example, free radicals in the form of peroxynitrite and superoxide oxidize DNA and other cellular macromolecules leading to apoptosis, also called programmed cell death. Free radical damage to the neuron after an ischemic insult activates the DNA repair enzyme Poly-ADP-Ribose Polymerase (PARP), which has been implicated in triggering the translocation of Apoptosis Inducing Factor (AIF) from the mitochondria to the nucleus. AIF acts as an endonuclease, cleaving DNA, ultimately causing cell death. To date there are no neuroprotective therapies which effectively and safely spare neurons in humans during ischemia. Ceria nanoparticles have the potential to be a novel therapy because they exhibit profound free radical scavenging abilities and they readily cross the blood brain barrier. The aim of the current project is to determine the extent to which ceria nanoparticles scavenge free radicals by assessing the translocation of AIF to the nucleus after ischemia. Electrophoresis and western blot detection allows for quantifiable, accurate detection of AIF and PARP after ischemia. We hypothesize that treatment with ceria nanoparticles will significantly decrease AIF translocation and PARP production after an ischemic insult.



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